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Lipitrex Supplement Facts & Research
Each 4 softgels contain:
- Licorice Root Extract: 100mg
- Vitamin B5 (as d-calcium Pantothenate): 100mg
- Vitamin B6 (as Pyridoxine HCL): 25mg
- Pinnothin: 1500mg
- Chromium (as Chromium Polynicotinate): 100mcg
- Magnesium (as magnesium oxide) 100mg
- Citrus Aurantium Extract: 100mg
- CLA (from CLA oil): 1500mg
- Guarana Extract: 200mg
- Caffeine: 44mg
Licorice Root Extract. Licorice root has long been recognized as an herbal therapy in diabetes. One of the active components, glycyrrhizin, has anti-diabetic activity, helping improve tolerance to oral glucose (1). The flavonoids in licorice root can also help suppress abdominal fat accumulation in addition to its hypoglycemic effect (2).
Vitamin B5. Research has shown that supplementation with pantothenic acid (vitamin B5) deriviatives can l ower food intake, mean body weight, insulin and glucose levels, and decrease the content of triglycerides, total cholesterol and cholesterol esters in serum and fatty tissue (3). Pharmaceutical pantothenic acid analogues exist for the treatment of dyslipidemia (4).
Vitamin B6. Also called pyridoxine, this essential vitamin is an effective treatment for a multitude of conditions. In recent years, pyridoxine has received much attention for its role in reducing levels of detrimental homocysteine, which is a risk factor for cardiovascular disease. Homocysteine levels often increase with weight loss, and vitamin B6 supplementation during this period protects against increased homocysteine production during weight reduction (5). Furthermore, overweight and obese children consume less of this vitamin for breakfast as compared with children who are normal weight and this may increase the risk of obesity (6).
Pinnothin. Derived from the seeds of the Korean Pine Nut tree Pinus koraenisis , this product (which just became widely available in 2005) contains pinolenic acid which helps suppress appetite by stimulating the appetite controlling hormone cholecystokinin (7).
Chromium. This required mineral is lacking in many diets and is vital to glucose metabolism as it is a cofactor for glucose tolerance factor. Chromium supplementation has been associated with an increase in lean body mass, a decrease in percentage body fat, and an increase in the basal metabolic rate (8-10). The results of a randomized double blind placebo controlled study of chromium supplementation suggest a relatively small reduction in body weight when compared with placebo during an intervention period of 6–14 weeks in patients with an average BMI of 28–33 (11). The meta-analysis of trials reported an absence of adverse effects.
Magnesium. Magnesium is increasingly studied in relation to obesity and insulin resistance. In fact a recent study showed that deficiency of magnesium is related to insulin resistance as early as childhood and suggested supplementation as an important tool in reducing diabetes in obese children (12). As well, low levels of magnesium prevalent in overweight and obese individuals may be an independent risk factor for cardiovascular disease (13, 14).
Citrus Aurantium Extract. Bitter orange is the common name for this medicinal plant which has an impressive body of research building for its use in weight reduction. A recent study demonstrated that administration of an extract of this plant results in increased thermic response to meals in women and does not cause increases in blood pressure or heart rate (15). A review of clinical studies concluded that citrus aurantium products “ may be the best thermogenic substitute for ephedra”, causing an increased metabolic rate (16).
CLA. A clinical study recently concluded, “ this study shows that CLA supplementation for 24 mo in healthy, overweight adults was well tolerated. It confirms also that CLA decreases BFM in overweight humans, and may help maintain initial reductions in BFM and weight in the long term (17)”. As well, CLA can reduce all parameters of appetite - hunger, satiety and fullness (18).
Guarana Extract. This supplement is derived from the seeds of Paullinia cupana. An herbal preparation from South America containing guarana extract demonstrated the ability to significantly delayed gastric emptying, reduced the time to perceived gastric fullness and induced significant weight loss over 45 days in a double-blind placebo-controlled parallel trial (19). Another randomized double blind trial examining the effect of a combination of Ma Huang and Guarana showed significant short term fat and weight loss (20).
Caffeine. Caffeine has long been used for weight loss due to its demonstrable thermogenic effects. A study published this year concluded that h igh caffeine intake was associated with weight loss through thermogenesis and fat oxidation and with suppressed leptin in women (21). Another randomized double-blind placebo-controlled clinical trial of a product containing ephedrine and caffeine showed that subjects taking the treatment experienced greater weight loss, without an increase in blood pressure, pulse, or the rate of adverse events, and in the absence of any lifestyle treatment to change dietary or exercise behavior (22).
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